The effects of the Modalert Tablet commonly last around 10 to 12 hours, although the exact duration can vary depending on factors such as dosage, metabolism, sleep quality, food intake, and individual sensitivity. Some people notice the effects wearing off gradually during the evening, while others may still feel mentally alert later into the night.

Because of its long-lasting effects, many users prefer taking the Modalert Tablet earlier in the morning to help reduce the chance of sleep disruption later in the day. Staying hydrated, maintaining regular sleep habits, and avoiding late-day use are also commonly mentioned as ways to support a smoother experience.